Mohler D G, Kessler J I, Earp B E
Division of Orthopaedics, Stanford University Medical School, CA, USA.
Clin Orthop Relat Res. 2000 Feb(371):183-97. doi: 10.1097/00003086-200002000-00023.
Ten patients who had amputations of a lower extremity for high-grade sarcomas underwent bone augmentation with either allograft or autograft between 1988 and 1996. There were eight transfemoral amputations and two transtibial amputations. The transferred segments consisted of one proximal tibia and six distal tibia autografts, two allografts, one autograft talar dome and first metatarsal, and one with a patellar cap of a supracondylar amputation. The average length of followup was 54 months. There were no nonunions of any of the grafts. There were three wound problems requiring additional operations. One autograft resorbed, and one autograft had a late infection. There was one local recurrence. Augmentation to provide length resulted in a 42% increase in bone length in those performed purely for length. All patients were able to use standard prostheses. Functional outcome was appropriate to the amputation level. Half of the patients avoided more proximal levels of amputation because of the ability to augment the osteotomy. The use of nonvascularized structural autografts or allografts is a simple procedure that can produce a superior residual limb in patients undergoing amputation. Its use should be considered in patients for whom traditional amputation techniques will result in poor function, difficulty in fitting a prosthesis, or greater than necessary anatomic loss.
1988年至1996年间,10例因高级别肉瘤行下肢截肢术的患者接受了同种异体骨或自体骨骨增强术。其中8例行经股骨截肢术,2例行经胫骨截肢术。移植节段包括1个近端胫骨和6个远端胫骨自体骨、2个同种异体骨、1个自体距骨穹窿和第一跖骨,以及1个髁上截肢的髌骨帽。平均随访时间为54个月。所有移植骨均未发生骨不连。有3例伤口问题需要再次手术。1个自体骨吸收,1个自体骨发生晚期感染。有1例局部复发。单纯为延长长度而进行的骨增强术使骨长度增加了42%。所有患者都能使用标准假肢。功能结果与截肢水平相适应。由于能够增加截骨长度,一半的患者避免了更高水平的截肢。使用非血管化结构性自体骨或同种异体骨是一种简单的手术方法,可为接受截肢术的患者产生更好的残肢。对于传统截肢技术会导致功能不佳、假肢适配困难或解剖学损失大于必要程度的患者,应考虑使用该方法。