Niewerth M, Korting H C
Dermatologische Klinik und Poliklinik, Ludwig-Maxamilians-Universität, Frauenlob-strasse 9-11, D-80337 München, Germany.
Eur J Dermatol. 2000 Mar;10(2):155-60.
Fungal infections of the skin as well as of the nails and hair due to dermatophytes or due to yeasts or moulds still form a major portion of skin diseases overall. Effective therapy of mycoses is not always simple to achieve. In less severe cases topical therapy can be sufficient, but in extensive cutaneous infections, previous resistance to treatment and especially hyperkeratotic tinea and onychomycosis, systemic therapy can be mandatory. For systemic therapy, in particular azoles, i.e. itraconazole and fluconazole as well as the allylamine terbinafine are worth considering. The older antimycotics, i.e. griseofulvin and also ketoconazole are more and more replaced by other, newer drugs. For optimal treatment of a given mycosis, therapy can and should correspond to the individual situation. This applies both to the type of drug and its mode of application. The treatment of choice is the one with the best benefit to risk ratio and the best benefit to cost ratio. Unfortunately, as yet, a cure cannot be expected in every single case.
由皮肤癣菌、酵母菌或霉菌引起的皮肤、指甲和毛发真菌感染，在所有皮肤病中仍占很大比例。真菌病的有效治疗并非总是容易实现。在不太严重的情况下，局部治疗可能就足够了，但在广泛的皮肤感染、既往治疗耐药尤其是角化过度型癣和甲癣中，全身治疗可能是必需的。对于全身治疗，特别是唑类药物，即伊曲康唑和氟康唑以及烯丙胺类特比萘芬值得考虑。较老的抗真菌药，即灰黄霉素以及酮康唑正越来越多地被其他更新的药物所取代。为了对特定的真菌病进行最佳治疗，治疗方法可以而且应该根据个体情况而定。这既适用于药物类型及其应用方式。选择的治疗方法是风险效益比和成本效益比最佳的方法。不幸的是，到目前为止，并非每个病例都能治愈。
