Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation.
作者信息
Högberg M, Engelhardt P, Vrang L, Zhang H
机构信息
Medivir AB, Huddinge, Sweden.
出版信息
Bioorg Med Chem Lett. 2000 Feb 7;10(3):265-8. doi: 10.1016/s0960-894x(99)00675-7.
Abstract
Bioisosteric substitution of the thiourea (3, 5, 7, 9) and urea (10) moiety of PETT compounds with sulfamide (1), cyanoguanidine (2, 4) and guanidine (6, 8) functionalities, and replacement of the phenethyl group with benzoylethyl group (compounds 11-20) have been studied. Synthesis and antiviral activities are described.
摘要
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