无菌F344大鼠自发性肿瘤的发生情况。

Occurrence of spontaneous tumors in the germfree F344 rat.

作者信息

Sacksteder M R

出版信息

J Natl Cancer Inst. 1976 Dec;57(6):1371-3. doi: 10.1093/jnci/57.6.1371.

DOI:10.1093/jnci/57.6.1371

Abstract

The incidence of spontaneously occurring neoplasms was observed over 10 years in a colony of germfree F344 rats (78 males and 102 females) representing 10 generations of inbredding. Leukemia was the most common neoplasm (25.6% of males, 36% of females) followed by mammary tumors (11.5% of males, 19.6% of females). Various other tumors developed in 9% of the males and 5% of the females. The overall incidence of spontaneous tumors was comparable to that reported for conventional rats of different strains. This was particularly true of leukemia for which the most data were available. However, for unknown reasons, significantly fewer solid tumors were observed in germfree than in conventional male rats.

摘要

在一个代表10代近亲繁殖的无菌F344大鼠群体（78只雄性和102只雌性）中，对自发肿瘤的发生率进行了为期10年的观察。白血病是最常见的肿瘤（雄性为25.6%，雌性为36%），其次是乳腺肿瘤（雄性为11.5%，雌性为19.6%）。9%的雄性和5%的雌性出现了各种其他肿瘤。自发肿瘤的总体发生率与不同品系常规大鼠的报告发生率相当。对于白血病尤其如此，因为有最多的数据可用。然而，由于未知原因，无菌雄性大鼠中观察到的实体瘤明显少于常规雄性大鼠。