藤仓赤霉菌对18-羟基-9-表-内-贝壳杉-7,15-二烯的生物转化

The biotransformation of 18-hydroxy-9-epi-ent-pimara-7,15-diene by Gibberella fujikuroi.

作者信息

Fraga B M, Hernández M G, González P, Chamy M C, Garbarino J A

机构信息

Instituto de Productos Naturales y Agrobiología, Tenerife, Canary Islands, Spain.

出版信息

Phytochemistry. 2000 Feb;53(3):395-9. doi: 10.1016/s0031-9422(99)00542-7.

DOI:10.1016/s0031-9422(99)00542-7

PMID:10703064

Abstract

Incubation of 18-hydroxy-9-epi-ent-pimara-7,15-diene with the fungus Gibberella fujikuroi gave the compounds 18-hydroxy-7 alpha,8 alpha-epoxy-9-epi-ent-pimara-15-ene, 18-hydroxy-7-oxo-ent-pimara-15-ene, 6 beta, 18-dihydroxy-7 alpha, 8 alpha-epoxy-9-epi-ent-pimara-15-ene, 9 beta,18-dihydroxy-7 alpha, 8 alpha-epoxy-ent-pimara-15-ene and 6 beta, 14 alpha, 18-trihydroxy-9-epi-ent-pimara-7,15-diene. Oxidation of C-19, which is characteristic of the biosynthesis pathway of the gibberellins is not produced.

摘要

将18 - 羟基 - 9 - 表 - 对映 - 海松 - 7,15 - 二烯与藤仓赤霉菌一起培养，得到了化合物18 - 羟基 - 7α,8α - 环氧 - 9 - 表 - 对映 - 海松 - 15 - 烯、18 - 羟基 - 7 - 氧代 - 对映 - 海松 - 15 - 烯、6β,18 - 二羟基 - 7α,8α - 环氧 - 9 - 表 - 对映 - 海松 - 15 - 烯、9β,18 - 二羟基 - 7α,8α - 环氧 - 对映 - 海松 - 15 - 烯以及6β,14α,18 - 三羟基 - 9 - 表 - 对映 - 海松 - 7,15 - 二烯。未发生赤霉素生物合成途径所特有的C - 19氧化反应。