马其顿人群中的HLA - DRB和 - DQB1基因多态性

HLA-DRB and -DQB1 polymorphism in the Macedonian population.

作者信息

Hristova-Dimceva A, Verduijn W, Schipper R F, Schreuder G M

机构信息

Institute of Blood Transfusion, Skopje, Republic of Macedonia.

出版信息

Tissue Antigens. 2000 Jan;55(1):53-6. doi: 10.1034/j.1399-0039.2000.550109.x.

DOI:10.1034/j.1399-0039.2000.550109.x

PMID:10703609

Abstract

HLA-DRB1, DRB3/4/5 and DQB1 polymorphism has been studied in a population of 80 unrelated healthy Macedonians using molecular methods. Twenty-five different DRB1 alleles were identified of which DRB11104, 1501, 1601, and 1101 were found most frequently. Among the 15 identified DQB1 alleles, two were predominant: DQB10301 and 0502. The most frequent three-locus haplotypes were DRB11104-DRB302-DQB10301 (18%/), DRB11101-DRB302-DQB10301 (9%) and DRB11601-DRB502-DQB10502 (10%). Polymorphism for DRB104, 13 and 15 haplotypes was extensive. Eleven different DR2-related haplotypes were found, some of which were unusual for European populations: DRB11501-DRB50102-DQB10502, DRB11501-DRB502-DQB10502, DRB11501-DRB50102-DQB1*0601.

摘要

已采用分子方法对80名无亲缘关系的健康马其顿人群体进行了HLA - DRB1、DRB3/4/5和DQB1多态性研究。共鉴定出25种不同的DRB1等位基因，其中DRB11104、1501、1601和1101最为常见。在鉴定出的15种DQB1等位基因中，有两种占主导地位：DQB10301和0502。最常见的三位点单倍型为DRB11104 - DRB302 - DQB10301（18%）、DRB11101 - DRB302 - DQB10301（9%）和DRB11601 - DRB502 - DQB10502（10%）。DRB104、13和15单倍型的多态性广泛。发现了11种不同的DR2相关单倍型，其中一些在欧洲人群中并不常见：DRB11501 - DRB50102 - DQB10502、DRB11501 - DRB502 - DQB10502、DRB11501 - DRB50102 - DQB1*0601。