用于选择性测定舒必利的电位传感器。

Potentiometric sensors for the selective determination of sulbutiamine.

作者信息

Ahmed M A, Elbeshlawy M M

机构信息

Chemistry Department, University College for Girls, Ain Shams University, Heliopolis, Cairo, Egypt.

出版信息

J Pharm Biomed Anal. 1999 Nov;21(2):415-21. doi: 10.1016/s0731-7085(99)00155-7.

DOI:10.1016/s0731-7085(99)00155-7

PMID:10703998

Abstract

Five novel polyvinyl chloride (PVC) matrix membrane sensors for the selective determination of sulbutiamine (SBA) cation are described. These sensors are based on molybdate, tetraphenylborate, reineckate, phosphotun gestate and phosphomolybdate, as possible ion-pairing agents. These sensors display rapid near-Nernstian stable response over a relatively wide concentration range 1x10(-2)-1x10(-6) M of sulbutiamine, with calibration slopes 28 32.6 mV decade(-1) over a reasonable pH range 2-6. The proposed sensors proved to have a good selectivity for SBA over some inorganic and organic cations. The five potentiometric sensors were applied successfully in the determination of SBA in a pharmaceutical preparation (arcalion-200) using both direct potentiometry and potentiometric titration. Direct potentiometric determination of microgram quantities of SBA gave average recoveries of 99.4 and 99.3 with mean standard deviation of 0.7 and 0.3 for pure SBA and arcalion-200 formulation respectively. Potentiometric titration of milligram quantities of SBA gave average recoveries of 99.3 and 98.7% with mean standard deviation of 0.7 and 1.2 for pure SBA and arcalion-200 formulation, respectively.

摘要

描述了用于选择性测定舒必利（SBA）阳离子的五种新型聚氯乙烯（PVC）基质膜传感器。这些传感器基于钼酸盐、四苯基硼酸盐、雷氏盐、磷钨酸盐和磷钼酸盐作为可能的离子对试剂。这些传感器在相对较宽的舒必利浓度范围1×10⁻² - 1×10⁻⁶ M内显示出快速的近能斯特稳定响应，在合理的pH范围2 - 6内校准斜率为28 - 32.6 mV/十倍浓度。所提出的传感器对SBA相对于一些无机和有机阳离子具有良好的选择性。这五种电位传感器已成功应用于使用直接电位法和电位滴定法测定药物制剂（阿卡丁 - 200）中的SBA。直接电位法测定微克量的SBA时，纯SBA和阿卡丁 - 200制剂的平均回收率分别为99.4%和99.3%，平均标准偏差分别为0.7和0.3。毫克量SBA的电位滴定中，纯SBA和阿卡丁 - 200制剂的平均回收率分别为99.3%和98.7%，平均标准偏差分别为0.7和1.2。