The mechanisms of action of interleukin-1 on rabbit intestinal epithelial cells.
作者信息
Homaidan F R, Zhao L, Chakroun I, Martin C A, Burakoff R
机构信息
Department of Physiology, Faculty of Medicine, American University of Beirut, Lebanon.
出版信息
Mediators Inflamm. 1999;8(4-5):189-97. doi: 10.1080/09629359990342.
Abstract
Interleukin-1 (IL-1) is an inflammatory mediator that increases Cl- secretion in intestinal epithelial cells. To identify the signal transduction pathway(s) involved in IL-1's action, cells were treated with IL-1 and the levels of cyclooxygenase (COX) enzymes, prostaglandin E2 (PGE2) and phospholipase A2-activating protein (PLAP), and the activity of phospholipase A2 (PLA2) were measured. IL-1 caused concentration- and time-dependent increases in the levels of PLA2 activity, and/or in the levels of PLAP, COX-2 and PGE2. The IL-induced increase in PGE2 levels was biphasic, with the first peak due to the increase in PLAP levels, and the second peak due to the increase in COX-2 levels. This increase in PGE2 levels may provide a mechanism for acute and chronic inflammation in the intestine.
摘要
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本文引用的文献
1
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Am J Physiol. 1997 Jun;272(6 Pt 1):G1338-46. doi: 10.1152/ajpgi.1997.272.6.G1338.
2
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.
Cell. 1995 Nov 3;83(3):483-92. doi: 10.1016/0092-8674(95)90126-4.
3
Responses of purified phospholipases A2 to phospholipase A2 activating protein (PLAP) and melittin.
Biochim Biophys Acta. 1993 Feb 10;1166(1):124-30. doi: 10.1016/0005-2760(93)90292-h.
4
Interleukin 1 signaling occurs exclusively via the type I receptor.
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6155-9. doi: 10.1073/pnas.90.13.6155.
5
Functional interleukin-2 receptors on intestinal epithelial cells.
J Clin Invest. 1993 Jul;92(1):527-32. doi: 10.1172/JCI116598.
6
Identification and characterization of the rat intestinal epithelial cell (IEC-18) interleukin-1 receptor.
Am J Physiol. 1994 May;266(5 Pt 1):C1198-203. doi: 10.1152/ajpcell.1994.266.5.C1198.
7
Bradykinin and FMLP stimulate prostanoid production by adult rabbit colonocytes in culture.
Am J Physiol. 1994 Nov;267(5 Pt 1):G778-85. doi: 10.1152/ajpgi.1994.267.5.G778.
8
Caco-2 cells express type I interleukin-1 receptors: ligand binding enhances proliferation.
Am J Physiol. 1994 Dec;267(6 Pt 1):G1101-7. doi: 10.1152/ajpgi.1994.267.6.G1101.
9
10
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
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