果蝇区域特异性模式形成基因teashirt的脊椎动物直系同源基因。

Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt.

作者信息

Caubit X, Coré N, Boned A, Kerridge S, Djabali M, Fasano L

机构信息

Upres Biodiversité, Laboratoire de Biologie Animale, Université de Provence, 3 Place Victor Hugo, Case 18, 13331, Marseille, France.

出版信息

Mech Dev. 2000 Mar 1;91(1-2):445-8. doi: 10.1016/s0925-4773(99)00318-4.

DOI:10.1016/s0925-4773(99)00318-4

PMID:10704881

Abstract

In Drosophila the teashirt gene, coding for a zinc finger protein, is active in specific body parts for patterning. For example, Teashirt is required in the trunk (thorax and abdomen) tagmata of the embryo, parts of the intestine and the proximal parts of appendages. Here we report the isolation of vertebrate cDNAs related to teashirt. As in Drosophila, human and murine proteins possess three widely spaced zinc finger motifs. Additionally, we describe the expression patterns of the two murine genes. Both genes show regionalized patterns of expression, in the trunk, in the developing limbs and the gut.

摘要

在果蝇中，编码锌指蛋白的teashirt基因在特定身体部位发挥作用以形成图案。例如，在胚胎的躯干（胸部和腹部）体节、部分肠道以及附肢的近端部位，Teashirt是必需的。在此，我们报告了与teashirt相关的脊椎动物cDNA的分离情况。与果蝇一样，人类和小鼠的蛋白质都拥有三个间隔较宽的锌指基序。此外，我们描述了两个小鼠基因的表达模式。这两个基因在躯干、发育中的四肢和肠道中均呈现出区域化的表达模式。