Tsunoda M, Sharma R P
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
J Trace Elem Med Biol. 1999 Dec;13(4):224-31. doi: 10.1016/S0946-672X(99)80040-6.
Aluminum, a known neurotoxic substance, has been suggested as a possible contributing factor in the pathogenesis of Alzheimer's disease. Ground-water pollution by aluminum has been recently reported. In the current study groups of 5 male BALB/c mice were administered aluminum ammonium sulfate in drinking water ad libitum at 0, 5, 25, and 125 mg/L aluminum for 4 weeks. At the termination of aluminum exposure, their brains were removed and dissected into cerebrum, cerebellum, medulla oblongata, midbrain, corpus striatum, and hypothalamus. The concentration of norepinephrine (NE), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA), were determined in each brain area. DA, DOPAC, and HVA levels were lower in the hypothalamus of aluminum-treated mice, most notably in the low-dose group, as compared with control. No marked alterations in NE, 5-HT, and 5-HIAA levels were detected in any brain region. Changes in the concentration of DA and its metabolites measured in the hypothalamus suggest an inhibition of DA synthesis by aluminum.
铝是一种已知的神经毒性物质，被认为可能是阿尔茨海默病发病机制中的一个促成因素。最近有报道称铝污染了地下水。在当前的研究中，将5只雄性BALB/c小鼠分为一组，分别给予含0、5、25和125mg/L铝的硫酸铝铵饮用水，自由饮用4周。在铝暴露结束时，取出它们的大脑并解剖成大脑、小脑、延髓、中脑、纹状体和下丘脑。测定每个脑区中去甲肾上腺素（NE）、多巴胺（DA）、二羟基苯乙酸（DOPAC）、高香草酸（HVA）、5-羟色胺（5-HT）和5-羟基吲哚乙酸（5-HIAA）的浓度。与对照组相比，铝处理小鼠下丘脑的DA、DOPAC和HVA水平较低，在低剂量组中最为明显。在任何脑区均未检测到NE、5-HT和5-HIAA水平有明显变化。在下丘脑中测得的DA及其代谢产物浓度的变化表明铝抑制了DA的合成。
