Tsai L H, Huang L R, Chen S H, Liu H J, Chou L S
Department of Physiology, School of Medicine, Taipei Medical College, Taiwan, ROC.
Chin J Physiol. 1999 Sep 30;42(3):181-7.
The effect of intravenous administration of L-glutamic acid (L-Glu) on gastric acid secretion and gastric mucosal blood flow (GMBF) in anesthetized rats were investigated. Infusion with synthetic L-Glu alone had no effect on spontaneous acid secretion. However, L-Glu reduced histamine- (2 mg/kg/hr) or oxotremorine- (1 microg/kg/hr) stimulated acid secretion, whereas L-Glu had no effect on acid secretion induced by pentagastrin (8 microg/kg/hr). Furthermore, this inhibitory effect of L-Glu on histamine- or oxotremorine-stimulated acid secretion was blocked by 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA receptor antagonist. The effect of L-Glu on gastric mucosal microcirculation in the anesthetized rats was evaluated by using Laser Doppler Flowmetry (LDF). The results showed that L-Glu did not significantly reduce both mucosal and serosal blood flow in stomach. No significant modulatory effect on histamine- or oxotremorine-stimulated increase in GMBF was noted after infusion with L-Glu. It is concluded that L-glutamic acid is capable of the modulating of gastric acid secretion via ionotropic non-NMDA receptors, but do not affect on GMBF. However, L-glutamic acid showed no effect on acid secretion by itself.
研究了静脉注射L-谷氨酸（L-Glu）对麻醉大鼠胃酸分泌和胃黏膜血流量（GMBF）的影响。单独输注合成L-Glu对自发胃酸分泌无影响。然而，L-Glu可降低组胺（2mg/kg/hr）或氧化震颤素（1μg/kg/hr）刺激的胃酸分泌，而L-Glu对五肽胃泌素（8μg/kg/hr）诱导的胃酸分泌无影响。此外，L-Glu对组胺或氧化震颤素刺激的胃酸分泌的这种抑制作用被非NMDA受体拮抗剂6,7-二硝基喹喔啉-2,3-二酮（DNQX）阻断。采用激光多普勒血流仪（LDF）评估L-Glu对麻醉大鼠胃黏膜微循环的影响。结果表明，L-Glu并未显著降低胃黏膜和浆膜血流量。输注L-Glu后，未观察到对组胺或氧化震颤素刺激的GMBF增加有明显的调节作用。得出结论，L-谷氨酸能够通过离子型非NMDA受体调节胃酸分泌，但对GMBF无影响。然而，L-谷氨酸本身对胃酸分泌无影响。
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