强迫症、惊恐障碍患者及健康对照者尾状核区域脑血流的单光子发射计算机断层扫描研究

Caudate regional cerebral blood flow in obsessive-compulsive disorder, panic disorder and healthy controls on single photon emission computerised tomography.

作者信息

Lucey J V, Costa D C, Busatto G, Pilowsky L S, Marks I M, Ell P J, Kerwin R W

机构信息

Department of Psychological Medicine, St. Bartholomew's and The Royal London School of Medicine and Dentistry, West Smithfield, UK.

出版信息

Psychiatry Res. 1997 Mar 14;74(1):25-33. doi: 10.1016/s0925-4927(96)03017-x.

DOI:10.1016/s0925-4927(96)03017-x

PMID:10710160

Abstract

We compared regional cerebral blood flow (rCBF) in 15 patients with DSM IIIR obsessive-compulsive disorder (OCD), 15 patients with DSM IIIR panic disorder and 15 healthy controls matched for age, sex and hand preference, using uptake of technetium-99m-D,L-hexamethyl-propylene amine oxime (99mTc HMPAO), on single photon emission computerised tomography (SPECT). Caudate rCBF was significantly reduced in OCD patients compared to healthy subjects and panic disorder patients. When four patients were excluded from each group, right caudate rCBF remained significantly lower in OCD patients than in panic disorder patients or healthy subjects. The data suggest functional involvement of the right caudate nucleus is present in OCD.

摘要

我们使用锝-99m-D，L-六甲基丙烯胺肟（99mTc HMPAO）摄取，通过单光子发射计算机断层扫描（SPECT），比较了15名符合DSM IIIR强迫症（OCD）的患者、15名符合DSM IIIR惊恐障碍的患者以及15名在年龄、性别和利手方面相匹配的健康对照者的局部脑血流量（rCBF）。与健康受试者和惊恐障碍患者相比，OCD患者的尾状核rCBF显著降低。当每组排除4名患者后，OCD患者右侧尾状核rCBF仍显著低于惊恐障碍患者或健康受试者。数据表明右侧尾状核在OCD中存在功能受累。