小GTP酶的Ras分支：Ras家族成员与其同类相差不大。

The Ras branch of small GTPases: Ras family members don't fall far from the tree.

作者信息

Reuther G W, Der C J

机构信息

Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, North Carolina 27599-7295, USA.

出版信息

Curr Opin Cell Biol. 2000 Apr;12(2):157-65. doi: 10.1016/s0955-0674(99)00071-x.

DOI:10.1016/s0955-0674(99)00071-x

PMID:10712923

Abstract

The Ras branch of the Ras superfamily consists of small GTPases most closely related to Ras and include the R-Ras, Rap, Ral, Rheb, Rin and Rit proteins. Although our understanding of Ras signaling and biology is now considerable, recent observations suggest that Ras function is more complex than previously believed. First, the three Ras proteins may not be functionally identical. Second, Ras function involves functional cross-talk with their close relatives.

摘要

Ras超家族的Ras分支由与Ras关系最为密切的小GTP酶组成，包括R-Ras、Rap、Ral、Rheb、Rin和Rit蛋白。尽管我们目前对Ras信号传导和生物学的理解已经相当深入，但最近的观察结果表明，Ras的功能比以前认为的更为复杂。首先，三种Ras蛋白在功能上可能并不相同。其次，Ras的功能涉及其近亲之间的功能性相互作用。