Isaksson M, Bruze M, Goossens A, Lepoittevin J P
Department of Occupational and Environmental Dermatology, Malmö University Hospital, Sweden.
Acta Derm Venereol. 2000 Jan-Feb;80(1):33-8. doi: 10.1080/000155500750012496.
Of patch-tested patients with dermatitis, 4-5% are allergic to corticosteroids. Four groups of corticosteroids are recognized (A-D), where substances from the same group may cross-react. We investigated the potential cross-reactivity pattern and dose-response relationship for several corticosteroids from group A. We also included the corresponding aldehyde to hydrocortisone, as this degradation product has been proposed to be immunogenic. Eleven patients shown to be allergic to tixocortol pivalate were patch-tested with several corticosteroids from group A, as well as with the aldehyde, all in serial dilutions. All 11 reacted to both tixocortol pivalate and hydrocortisone. The dose-response relationship for the corticosteroids tended to be similar to sensitizers lacking anti-inflammatory potential. Patients with simultaneous reactions to many substances had high patch-test reactivity to tixocortol pivalate and hydrocortisone, while patients with few such reactions showed low reactivity (p=0.001 and 0.003, respectively). Several patients reacted to the aldehyde, supporting the theory that it is an intermediate in sensitization.
在进行斑贴试验的皮炎患者中，4%至5%对皮质类固醇过敏。皮质类固醇分为四组（A - D），同一组中的物质可能会发生交叉反应。我们研究了A组几种皮质类固醇的潜在交叉反应模式和剂量反应关系。我们还纳入了氢化可的松对应的醛，因为有人提出这种降解产物具有免疫原性。对11名显示对特戊酸替可的松过敏的患者用A组的几种皮质类固醇以及醛进行了斑贴试验，所有均为系列稀释液。所有11名患者对特戊酸替可的松和氢化可的松均有反应。皮质类固醇的剂量反应关系往往与缺乏抗炎潜力的致敏剂相似。对多种物质同时有反应的患者对特戊酸替可的松和氢化可的松的斑贴试验反应性高，而此类反应少的患者反应性低（分别为p = 0.001和0.003）。几名患者对醛有反应，支持了其为致敏过程中间产物的理论。
Zotero 插件