家族性高胆固醇血症中的血浆脂蛋白(a)值及其与冠心病的关系。

Plasma Lp(a) values in familial hypercholesterolemia and its relation to coronary heart disease.

作者信息

Real J T, Ascaso J F, Chaves F J, Tenés S, Priego M A, Puig O, Armengod M E, Carmena R

机构信息

Endocrine Service, Hospital Clinico Universitario, University of Valencia, Spain.

出版信息

Nutr Metab Cardiovasc Dis. 1999 Feb;9(1):41-4.

PMID:10726108

Abstract

BACKGROUND AND AIM

To analyze plasma Lp(a) levels and examine different risk factors and coronary heart disease (CHD) in a sample of genetically diagnosed familial hypercholesterolemia (FH) patients.

METHODS AND RESULTS

Ninety heterozygous FH patients and 41 non-FH relatives were enrolled in a study to evaluate their plasma and lipoprotein cholesterol, as well as their triglyceride and Lp(a) levels. We found no differences in plasma Lp(a) levels and log transformed values between 90 FH subjects and their 41 unaffected relatives (22.3 mg/dl +/- 19.4 vs 17.7 mg/dl +/- 21.3 and 1.12 +/- 0.5 vs 0.96 +/- 0.54) nor between null allele and defective allele FH subjects (log Lp (a) levels 2.013 +/- 0.282 vs 1.959 +/- 0.151). FH CHD+ were significantly older, and had higher mean systolic and diastolic blood pressure and higher mean plasma triglyceride levels than FH CHD-. No differences in mean and log transformed Lp(a) plasma concentrations were found.

CONCLUSIONS

Plasma Lp(a) levels are not related to LDL receptor status and class mutations, nor to the presence of CHD in FH patients.

摘要

背景与目的

分析经基因诊断的家族性高胆固醇血症（FH）患者样本中的血浆Lp(a)水平，并研究不同风险因素与冠心病（CHD）的关系。

方法与结果

90例杂合子FH患者和41例非FH亲属参与了一项研究，以评估他们的血浆和脂蛋白胆固醇水平，以及甘油三酯和Lp(a)水平。我们发现，90例FH受试者与其41例未受影响的亲属之间，血浆Lp(a)水平和对数转换值无差异（分别为22.3mg/dl±19.4与17.7mg/dl±21.3，以及1.12±0.5与0.96±0.54），无效等位基因与缺陷等位基因的FH受试者之间也无差异（Lp(a)对数水平为2.013±0.282与1.959±0.151）。FH CHD+患者比FH CHD-患者年龄显著更大，平均收缩压和舒张压更高，平均血浆甘油三酯水平更高。血浆Lp(a)平均浓度和对数转换浓度无差异。