抗孕激素的临床应用。

Clinical uses of antiprogestogens.

作者信息

Baird D T

机构信息

Department of Obstetrics/Gynecology, University of Edinburgh, Scotland, UK.

出版信息

J Soc Gynecol Investig. 2000 Jan-Feb;7(1 Suppl):S49-52. doi: 10.1016/s1071-5576(99)00063-5.

DOI:10.1016/s1071-5576(99)00063-5

PMID:10732330

Abstract

Progesterone is essential to the establishment and maintenance of pregnancy. Compounds that inhibit the synthesis of progesterone, or antagonize progesterone action, have multiple effects including the induction of abortion, labor induction, contraception, and cervical ripening. They also may be used in the treatment of endometriosis, fibromyomata, meningiomas, Cushing syndrome, and glaucoma. Antiprogesterone compounds will play important roles in manipulating reproductive function for fertility control and in the treatment of hormone-dependent disease. This article reviews the potential of antiprogesterone compounds.

摘要

孕酮对于妊娠的建立和维持至关重要。抑制孕酮合成或拮抗孕酮作用的化合物具有多种作用，包括诱导流产、引产、避孕和促进宫颈成熟。它们还可用于治疗子宫内膜异位症、子宫肌瘤、脑膜瘤、库欣综合征和青光眼。抗孕酮化合物在控制生育的生殖功能调节以及激素依赖性疾病的治疗中将发挥重要作用。本文综述了抗孕酮化合物的潜力。