Electron-microscopic immunocytochemical study of the intracellular transport of the viral glycoproteins in ts1, a mutant of Moloney murine leukemia virus.
作者信息
Roussev R, Shikova E, Sovová V, Stokrová J, Alexandrov M
机构信息
Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Sofia.
出版信息
Folia Biol (Praha). 1998;44(4):123-6.
PMID:10732700
Abstract
The transport and localization of env-proteins of ts1 virus (a paralytogenic temperature-sensitive mutant of Moloney murine leukemia virus) in infected cells of the TB cell line have been studied at the ultrastructural level. It was found that the envelope precursor polyprotein gPr80-env of ts1 was inefficiently transported out of the endoplasmic reticulum at the restrictive temperature. It was speculated that inefficient transport correlates with inefficient processing of gPr80env into gp70 and Prp15E and leads to paralytic disease.
摘要
相似文献
1
2
A Val-25-to-Ile substitution in the envelope precursor polyprotein, gPr80env, is responsible for the temperature sensitivity, inefficient processing of gPr80env, and neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.
J Virol. 1990 Feb;64(2):467-75. doi: 10.1128/JVI.64.2.467-475.1990.
3
Oligomerization and transport of the envelope protein of Moloney murine leukemia virus-TB and of ts1, a neurovirulent temperature-sensitive mutant of MoMuLV-TB.
Virology. 1991 Oct;184(2):687-94. doi: 10.1016/0042-6822(91)90438-h.
4
Murine leukemia virus induced central nervous system diseases.
Leukemia. 1992;6 Suppl 3:161S-165S.
5
Role of cell cytoskeleton in Mo-MuLV env transport and processing: implications in ts1 neuropathology.
Exp Mol Pathol. 1987 Jun;46(3):294-311. doi: 10.1016/0014-4800(87)90051-7.
6
Correlation of specific virus-astrocyte interactions and cytopathic effects induced by ts1, a neurovirulent mutant of Moloney murine leukemia virus.
J Virol. 1993 Mar;67(3):1137-47. doi: 10.1128/JVI.67.3.1137-1147.1993.
7
Quantitation of MoMuLV envelope protein on the cell surface.
Virology. 1998 Apr 10;243(2):415-22. doi: 10.1006/viro.1998.9073.
8
Analysis of cysteine mutations on the transmembrane protein of Moloney murine leukemia virus.
Virology. 1995 Aug 1;211(1):285-9. doi: 10.1006/viro.1995.1402.
9
A 1.6-kilobase-pair fragment in the genome of the ts1 mutant of Moloney murine leukemia virus TB that is associated with temperature sensitivity, nonprocessing of Pr80env, and paralytogenesis.
J Virol. 1985 May;54(2):364-73. doi: 10.1128/JVI.54.2.364-373.1985.
10
Construction and characterization of expression systems for the env gene of ts1, a mutant of Moloney murine leukemia virus-TB.
Virus Res. 1991 Mar;19(1):83-92. doi: 10.1016/0168-1702(91)90096-e.
Zotero 插件