[Insulin-like growth factor binding protein 1 (IGFBP-1) in vaginal secretion as a marker of premature rupture of amniotic membranes].

Diagnosis of premature rupture of amniotic membranes in premature pregnancy allows to estimate dangers which threaten foetus and pregnant woman and helps to put into practice the most accurate therapeutics procedures. The aim of this study was to prove the clinical usefulness of test detecting insulin-like growth factor binding protein-1 in vaginal secretion for diagnose of premature rupture of amniotic membranes and compare the sensiviteness and specificity the above test with Gram stained vaginal smears. We examined group of 50 pregnant women between 25 and 42 week of pregnancy treated in Department of Fertility and Obstetrics Medical University of Wrocław. Pregnant women were divided into 3 groups. In each of them both tests were performed to diagnose premature rupture of amniotic membranes. Achieved scores shows that Amni Check is specific and sensitive test detecting even insignificant premature rupture of amniotic membranes and has higher sensitivity comparing with common method used until now for detection of premature rupture of amniotic membranes based on Gramm stained vaginal secretion.