Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation.
作者信息
Altomare C, Summo L, Cellamare S, Varlamov A V, Voskressensky L G, Borisova T N, Carotti A
机构信息
Dipartimento Farmacochimico, Università degli Studi, Bari, Italy.
出版信息
Bioorg Med Chem Lett. 2000 Mar 20;10(6):581-4. doi: 10.1016/s0960-894x(00)00052-4.
Abstract
A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by adenosin 5'-diphosphate (ADP). Structure-activity relationships showed their antiplatelet effects to be related to the lipophilicity.
摘要
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