诺氏疟原虫连续红细胞期的抗原分析。

Antigenic analysis of sequential erythrocytic stages of Plasmodium knowlesi.

作者信息

Deans J A, Dennis E D, Cohen S

出版信息

Parasitology. 1978 Dec;77(3):333-44. doi: 10.1017/s0031182000050290.

DOI:10.1017/s0031182000050290

Abstract

The antigenic composition of sequential erythrocytic stages of Plasmodium knowlesi has been compared by crossed immuno-electrophoresis using a pool of immune rhesus monkey antiserum. Eleven major parasite antigens have been identified; 9 are stage-independent, and 2 stage-dependent. Differences in the relative amount of the stage-independent antigens have been demonstrated and quantified. The distribution of antigens between parasites and schizont and infected red cell membranes has been examined. Only 6 of the 11 parasite antigens were exhibited by a schizont membrane preparation, all these antigens were also expressed by the intracellular parasite. Antigens exclusive to the schizont membrane were not demonstrated.

摘要

利用恒河猴免疫血清池，通过交叉免疫电泳比较了诺氏疟原虫连续红细胞期的抗原组成。已鉴定出11种主要的寄生虫抗原；9种与阶段无关，2种与阶段有关。已证明并量化了与阶段无关的抗原相对量的差异。研究了抗原在寄生虫、裂殖体和感染红细胞膜之间的分布。11种寄生虫抗原中只有6种在裂殖体膜制剂中表现出来，所有这些抗原也在细胞内寄生虫中表达。未证明裂殖体膜特有的抗原。