Lacritz L H, Cullum C M, Frol A B, Dewey R B, Giller C A
University of Texas Southwestern Medical Center at Dallas, 75235-8898, USA.
Brain Cogn. 2000 Apr;42(3):364-78. doi: 10.1006/brcg.1999.1110.
Neuropsychological functioning was examined at baseline and 2- to 3-month follow-up in 40 subjects with advanced Parkinson's disease (PD) who underwent unilateral posteroventral pallidotomy. Most subjects demonstrated improved verbal learning, visual memory, confrontation naming, and figural fluency at follow-up. Right pallidotomy was associated with decreased cognitive flexibility and increased verbal fluency, whereas Left pallidotomy uniquely resulted in a decline in verbal fluency. Significant motor improvement was demonstrated in both groups. Pallidotomy appears to be an effective treatment for advanced PD, providing a significant improvement in motor functioning, while resulting in few deleterious neurocognitive changes in most cases.
对40例晚期帕金森病（PD）患者进行了单侧后腹侧苍白球切开术，并在基线以及2至3个月随访时对其神经心理功能进行了检查。大多数患者在随访时表现出言语学习、视觉记忆、对物命名和图形流畅性方面的改善。右侧苍白球切开术与认知灵活性降低和言语流畅性增加有关，而左侧苍白球切开术则唯一导致言语流畅性下降。两组均显示出显著的运动改善。苍白球切开术似乎是晚期PD的一种有效治疗方法，可显著改善运动功能，且在大多数情况下几乎不会导致有害的神经认知变化。
