Hellberg A, Christiansson L, Tulga Ulus A, Bergqvist D, Wiklund L, Karacagil S
Department of Surgery, University Hospital, Uppsala, Sweden.
Eur J Vasc Endovasc Surg. 2000 Mar;19(3):318-23. doi: 10.1053/ejvs.1999.1027.
to evaluate the effect of a modified aortic shunt on central haemodynamic variables during experimental thoracic aortic occlusion in a prolonged spinal cord ischaemia model.
central haemodynamic variables were evaluated during aortic cross-clamping. In the shunt group (n=11), after the placement of proximal and distal aortic clamps, distal aortic perfusion was restored through an aortoiliac shunt via the left subclavian artery. In the no-shunt group (n=11), spinal cord ischaemia was achieved with only proximal aortic cross-clamping. The clamping time was 60 minutes in the shunt group and 30 minutes in the no-shunt group.
in the no-shunt group, all animals needed inotropic support, vasodilators and buffers during the experiment. None of these drugs were needed in the shunt group. In the no-shunt group, cross-clamping caused a significant increase in mean arterial pressure and heart rate compared to baseline values. These variables were stable in the shunt group during aortic occlusion. In the reperfusion period cardiac output, heart rate and arterial pCO(2)were significantly higher in the no-shunt than in the shunt group.
the present experimental spinal cord ischaemia model, using double aortic cross-clamping with shunt, offers improved central haemodynamics. This enables the study of prolonged selective spinal cord ischaemia without interaction from vasoactive drugs or systemic reperfusion.
在延长的脊髓缺血模型中，评估改良主动脉分流术对实验性胸主动脉阻断期间中心血流动力学变量的影响。
在主动脉交叉钳夹期间评估中心血流动力学变量。在分流组（n = 11）中，在放置近端和远端主动脉夹后，通过经左锁骨下动脉的主髂分流术恢复远端主动脉灌注。在无分流组（n = 11）中，仅通过近端主动脉交叉钳夹实现脊髓缺血。分流组的钳夹时间为60分钟，无分流组为30分钟。
在无分流组中，所有动物在实验期间都需要使用正性肌力药物、血管扩张剂和缓冲剂。分流组不需要这些药物中的任何一种。在无分流组中，与基线值相比，交叉钳夹导致平均动脉压和心率显著升高。在主动脉阻断期间，这些变量在分流组中保持稳定。在再灌注期，无分流组的心输出量、心率和动脉pCO₂ 显著高于分流组。
目前使用带分流的双主动脉交叉钳夹的实验性脊髓缺血模型可改善中心血流动力学。这使得能够在不受血管活性药物或全身再灌注影响的情况下研究延长的选择性脊髓缺血。
