Michel O, Jahns T, Joost-Enneking M, Neugebauer P, Streppel M, Stennert E
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universität zu Köln.
HNO. 2000 Mar;48(3):182-8. doi: 10.1007/s001060050030.
The pathogenetic mechanisms of acute cochleo-vestibular lesions are still unknown, but viral infections and vascular phenomena with impairment of microvascular perfusion are thought to play a major role. Between 1 July, 1986 and 28 February 1998, 1501 patients were treated with an infusion protocol using cortisone, dextrane 40 and pentoxifylline. Group 1 contained 1001 patients with sudden hearing loss, group 2a 107 patients with isolated tinnitus and group 2b 393 patients with labyrinthine disorders (among which were 81 patients with cochleovestibular dysfunction). The records were evaluated retrospectively. In group 1 complete hearing recovery occurred in 44.8%, partially in 40.4%, no change in 12.1% and worsened in 2.6%. In group 2a with isolated tinnitus 17.9% had a complete recovery, 43.9% partial recovery, 35.5% no change and 2.8% worsened symptoms. In group 2b vertigo disappeared in 56.8%, had partial recovery in 21.0% and did not change in 7.4%. In the 1501 patients treated, no significant side-effects were found to the medical interventions used. From these results we conclude that the infusion protocol is safe and effective in the treatment of cochleo-vestibular disorders.
急性耳蜗 - 前庭病变的发病机制尚不清楚,但病毒感染和微血管灌注受损的血管现象被认为起主要作用。1986年7月1日至1998年2月28日期间,1501例患者采用含有可的松、右旋糖酐40和己酮可可碱的输注方案进行治疗。第1组包含1001例突发听力损失患者,第2a组107例单纯耳鸣患者,第2b组393例迷路疾病患者(其中81例患有耳蜗 - 前庭功能障碍)。对记录进行回顾性评估。第1组中,44.8%的患者听力完全恢复,40.4%部分恢复,12.1%无变化,2.6%听力恶化。在第2a组单纯耳鸣患者中,17.9%完全恢复,43.9%部分恢复,35.5%无变化,2.8%症状恶化。在第2b组中,56.8%的眩晕消失,21.0%部分恢复,7.4%无变化。在接受治疗的1501例患者中,未发现所用医疗干预措施有明显副作用。从这些结果我们得出结论,该输注方案在治疗耳蜗 - 前庭疾病方面是安全有效的。