Ceresini G, Morganti S, Rebecchi I, Freddi M, Ceda G P, Banchini A, Solerte S B, Ferrari E, Ablondi F, Valenti G
Department of Internal Medicine and Biochemical Sciences, University of Parma, Italy.
Metabolism. 2000 Apr;49(4):548-51. doi: 10.1016/s0026-0495(00)80024-4.
Aging is associated with a selective decline in circulating levels of dehydroepiandrosterone (DHEA) and its sulfate, with no major changes in cortisol secretion. In young subjects, serum levels of both DHEA and cortisol are regulated according to a circadian rhythm, and an age-related attenuation of DHEA, but not cortisol, circadian rhythmicity has been reported. Several trials have evaluated the effects of DHEA supplementation in elderly subjects, although the results are still controversial. However, no data are available on the 24-hour profile of DHEA circulating levels in elderly subjects with DHEA administration. In the present study, we evaluated the circadian rhythms of DHEA, cortisol, and the cortisol/DHEA molar ratio in old subjects treated with either placebo (old-PL) or a single 50-mg dose of DHEA (old-D), both administered orally at 0700 hours. For each variable, the circadian profiles were compared with those obtained in young control subjects. The group of young subjects displayed a circadian rhythm for both DHEA and cortisol serum concentrations but no rhythm for the cortisol/DHEA molar ratio. In the old-PL group, the circadian rhythm of DHEA was completely abolished, whereas significant rhythms for both cortisol and the cortisol/DHEA molar ratio were observed. Particularly, at each time point, the cortisol/DHEA molar ratio was significantly higher in these subjects versus the young group. In the old-D group, the circadian rhythm of DHEA was completely restored and was comparable to that observed in the young group. Analogous to the observations in young subjects, the profile of the cortisol/DHEA molar ratio in old-D subjects did not display any circadian rhythmicity, the values being almost completely comparable to those observed in young controls. Our data demonstrate that the circadian rhythm of DHEA is totally abolished in elderly subjects. A single 50-mg dose of DHEA administered orally at 0700 hours restores the circadian rhythmicity of serum DHEA and almost completely normalizes the 24-hour profile of the cortisol/DHEA molar ratio in old subjects without affecting the cortisol circadian rhythm.
衰老与循环中的脱氢表雄酮（DHEA）及其硫酸盐水平选择性下降有关，而皮质醇分泌无重大变化。在年轻受试者中，DHEA和皮质醇的血清水平均根据昼夜节律进行调节，并且有报道称DHEA的昼夜节律性随年龄衰减，而皮质醇则没有。几项试验评估了补充DHEA对老年受试者的影响，尽管结果仍存在争议。然而，关于给予DHEA的老年受试者DHEA循环水平的24小时变化情况尚无数据。在本研究中，我们评估了接受安慰剂（老年-PL）或单次口服50mg DHEA（老年-D）治疗的老年受试者中DHEA、皮质醇以及皮质醇/DHEA摩尔比的昼夜节律，给药时间均为上午7点。对于每个变量，将昼夜变化情况与年轻对照受试者的进行比较。年轻受试者组中，DHEA和皮质醇血清浓度均呈现昼夜节律，但皮质醇/DHEA摩尔比无节律。在老年-PL组中，DHEA的昼夜节律完全消失，而皮质醇和皮质醇/DHEA摩尔比均观察到显著节律。特别是，在每个时间点，这些受试者的皮质醇/DHEA摩尔比显著高于年轻组。在老年-D组中，DHEA的昼夜节律完全恢复，与年轻组观察到的情况相当。与年轻受试者的观察结果类似，老年-D受试者的皮质醇/DHEA摩尔比曲线未显示任何昼夜节律性，其值几乎与年轻对照组观察到的完全可比。我们的数据表明，老年受试者中DHEA的昼夜节律完全消失。上午7点口服单次50mg DHEA可恢复老年受试者血清DHEA的昼夜节律，并几乎完全使皮质醇/DHEA摩尔比的24小时变化情况正常化，且不影响皮质醇的昼夜节律。
Zotero 插件