Philipps B, Lörken M, Manegold E, Kasperk R, Schumpelick V
Chirurgische Universitätsklinik und Poliklinik, RWTH Aachen.
Chirurg. 2000 Mar;71(3):334-6.
Primary liposarcoma of the stomach wall is rare. Only eight cases have been described so far.
Here we report the ninth case, occurring in a 74-year-old woman who presented with weight loss and a therapy-resistant ulcer of the stomach wall.
Pre- and perioperative findings suggested a benign lipoma of the stomach wall. The patient was treated with subtotal gastrectomy. On microscopic examination the tumor showed features of a benign lipoma but for a distinctive capillary net. Immunohistochemically the S-100 reaction was positive. Less than 1% of Ki67-positive cells could be found, thus suggesting a highly differentiated primary liposarcoma of the stomach wall.
In situations where the benign or malignant nature of a submucosal lesion cannot be diagnosed with certainty a mesenchymal tumor of the stomach wall has to be included in the differential diagnosis. Here the indication for complete surgical excision and histological workup has to be set widely.
胃壁原发性脂肪肉瘤罕见。迄今为止,仅报道过8例。
在此,我们报告第9例病例,患者为一名74岁女性,表现为体重减轻和胃壁难治性溃疡。
术前及术中发现提示胃壁有一良性脂肪瘤。患者接受了胃次全切除术。显微镜检查显示肿瘤具有良性脂肪瘤的特征,但有独特的毛细血管网。免疫组化显示S-100反应阳性。Ki67阳性细胞不到1%,提示为胃壁高分化原发性脂肪肉瘤。
在无法明确诊断黏膜下病变的良恶性时,胃壁间叶性肿瘤必须纳入鉴别诊断。在此情况下,必须广泛设定完整手术切除和组织学检查的指征。