小剂量米索前列醇预防小剂量阿司匹林所致的胃十二指肠损伤。
Low-dose misoprostol for the prevention of low-dose aspirin-induced gastroduodenal injury.
作者信息
Donnelly M T, Goddard A F, Filipowicz B, Morant S V, Shield M J, Hawkey C J
机构信息
Division of Gastroenterology, University Hospital, Nottingham; Searle, High Wycombe, UK.
出版信息
Aliment Pharmacol Ther. 2000 May;14(5):529-34. doi: 10.1046/j.1365-2036.2000.00739.x.
INTRODUCTION
The harmful effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the gastric mucosa and the prophylactic effects of misoprostol are both dose-dependent.
AIM
To investigate whether a low-dose of misoprostol is sufficient to prevent gastric mucosal injury caused by low-dose aspirin.
METHODS
We conducted a double-blind placebo controlled parallel group endoscopic study in 32 evaluable volunteers. The main outcome measure was erosive injury (ulcers and superficial erosions) in the gastric mucosa over 28 days.
RESULTS
Most subjects developed erosions on aspirin 300 mg daily. This was significantly reduced by misoprostol 100 microg daily. (Odds ratio 0.18, 95% CI: 0.07-0.48). There were no drug-related or gastrointestinal adverse events in subjects receiving misoprostol.
CONCLUSION
Misoprostol 100 microg daily can prevent low-dose aspirin induced gastric mucosal injury without causing identifiable adverse effects.
引言
非甾体抗炎药（NSAIDs）对胃黏膜的有害作用以及米索前列醇的预防作用均呈剂量依赖性。
目的
研究低剂量米索前列醇是否足以预防低剂量阿司匹林所致的胃黏膜损伤。
方法
我们对32名可评估的志愿者进行了一项双盲、安慰剂对照的平行组内镜研究。主要观察指标为28天内胃黏膜的糜烂性损伤（溃疡和浅表糜烂）。
结果
大多数受试者每日服用300毫克阿司匹林时出现糜烂。每日服用100微克米索前列醇可显著减少这种情况。（比值比0.18，95%可信区间：0.07 - 0.48）。接受米索前列醇的受试者未出现与药物相关的或胃肠道不良事件。
结论
每日服用100微克米索前列醇可预防低剂量阿司匹林引起的胃黏膜损伤，且不会导致可识别的不良反应。
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