Schlager A, Mitterschiffthaler G, Pühringer F
Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University of Innsbruck, Austria.
Br J Anaesth. 2000 Mar;84(3):405-6. doi: 10.1093/oxfordjournals.bja.a013450.
We have investigated the effectiveness of rectally administered dimenhydrinate on postoperative vomiting in children undergoing strabismus surgery, in a double-blind, randomized, placebo-controlled study. In one group, dimenhydrinate 50 mg was administered rectally 30 min before starting anaesthesia, whereas in the control group, placebo suppositories were given. Children who received dimenhydrinate showed a significantly (P < 0.001) lower incidence of vomiting (15%) than those in the control group (75%). We conclude that rectal administration of dimenhydrinate is an effective means of reducing postoperative vomiting in children undergoing strabismus surgery.
在一项双盲、随机、安慰剂对照研究中，我们调查了直肠给药茶苯海明对斜视手术患儿术后呕吐的有效性。一组在麻醉开始前30分钟直肠给予50毫克茶苯海明，而对照组给予安慰剂栓剂。接受茶苯海明治疗的儿童呕吐发生率（15%）显著低于对照组（75%）（P<0.001）。我们得出结论，直肠给药茶苯海明是减少斜视手术患儿术后呕吐的有效方法。
