Bassil S, Wyns C, Donnez J
Centre hospitalier de Luxembourg, Department of Obstetrics and Gynecology, Grand Duchy of Luxembourg.
J Assist Reprod Genet. 2000 Feb;17(2):107-12. doi: 10.1023/a:1009418017662.
In the present study, we investigated the benefits of highly purified FSH (H.P. FSH) in comparison with human menopausal gonadotrophin (hMG) in IVF patients aged 37-41 years.
Twenty patients experienced within a period of four months both preparations in subsequent cycles through a prospective randomized cross-over design. A standard hormonal treatment consisting of a flare-up protocol using gonadotrophin-releasing hormone agonist (GnRHa) in combination with the same starting dose of H.P. FSH or hMG was used in all cycles.
Cycles stimulated with H.P. FSH resulted in a significantly higher mean number (10.3 +/- 3) of ovocytes retrieved with a significantly shorter (13 +/- 2.3 days) duration of stimulation compared to cycles treated with hMG [mean number of oocytes 7.3 +/- 5 (P < 0.01) and mean duration of stimulation 14.7 +/- 3.9 days (P < 0.02)]. No detrimental effect of basal or exogenous LH on oocyte quality was observed in our study.
In our experience, H.P. FSH preparations seemed to be more effective than hMG preparations for ovarian stimulation in this group of women aged 37-41 years.
在本研究中,我们调查了在37 - 41岁的体外受精(IVF)患者中,高纯度促卵泡激素(H.P. FSH)相较于人绝经期促性腺激素(hMG)的优势。
通过前瞻性随机交叉设计,20名患者在四个月内的后续周期中接受了这两种制剂的治疗。所有周期均采用标准激素治疗方案,即使用促性腺激素释放激素激动剂(GnRHa)进行激发方案,并联合相同起始剂量的H.P. FSH或hMG。
与使用hMG治疗的周期相比,使用H.P. FSH刺激的周期平均回收卵母细胞数量显著更高(10.3 ± 3),且刺激持续时间显著更短(13 ± 2.3天)[卵母细胞平均数量7.3 ± 5(P < 0.01),刺激平均持续时间14.7 ± 3.9天(P < 0.02)]。在我们的研究中未观察到基础或外源性促黄体生成素(LH)对卵母细胞质量有不利影响。
根据我们的经验,在这组37 - 41岁的女性中,H.P. FSH制剂在卵巢刺激方面似乎比hMG制剂更有效。