p24/ING1-ALT1和p47/ING1-ALT2，p33/ING1的不同可变转录本。
p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1.
作者信息
Saito A, Furukawa T, Fukushige S, Koyama S, Hoshi M, Hayashi Y, Horii A
机构信息
Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
出版信息
J Hum Genet. 2000;45(3):177-81. doi: 10.1007/s100380050206.
p33/ING1s (the growth inhibitor ING1 and candidate tumor suppressor ING1) are key players in the suppressive pathways for human tumorigenesis. We analyzed their complete transcripts, primary structures, and expression. The results led us to discover two novel and related alternatively spliced transcripts encoding p24/ING1-ALT1 and p47/ING1-ALT2. They share C-terminal residues with the candidate tumor suppressors p33/ING1. The candidate tumor suppressors p33/ING1 and p24/ING1-ALT1 were coexpressed in a variety of fetal and adult human tissues, but p47/ING1-ALT2 was minimally expressed.
p33/ING1s（生长抑制因子ING1和候选肿瘤抑制因子ING1）是人类肿瘤发生抑制途径中的关键因子。我们分析了它们的完整转录本、一级结构和表达情况。结果使我们发现了两种新的且相关的可变剪接转录本，分别编码p24/ING1-ALT1和p47/ING1-ALT2。它们与候选肿瘤抑制因子p33/ING1共享C端残基。候选肿瘤抑制因子p33/ING1和p24/ING1-ALT1在多种胎儿和成人组织中共同表达，但p47/ING1-ALT2的表达量极低。
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