一氧化氮与间质性肺疾病
Nitric oxide and interstitial lung disease.
作者信息
Suga M, Okamoto T, Ando M
机构信息
First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
出版信息
Curr Opin Pulm Med. 1998 Sep;4(5):251-5. doi: 10.1097/00063198-199809000-00002.
The role and significance of nitric oxide (NO) and its intermediates on interstitial lung diseases are discussed. NO itself has protective roles against lung injury; however, NO is converted to peroxynitrite through the reaction with the superoxide anion at the inflammation foci, resulting in various destructive effects against lung parenchyma. Increased production of NO and peroxynitrite play an important role in oxidative injury and remodeling associated with interstitial lung diseases.
讨论了一氧化氮（NO）及其中间体在间质性肺疾病中的作用和意义。NO本身对肺损伤具有保护作用；然而，在炎症灶处，NO通过与超氧阴离子反应转化为过氧亚硝酸盐，从而对肺实质产生各种破坏作用。NO和过氧亚硝酸盐生成增加在与间质性肺疾病相关的氧化损伤和重塑中起重要作用。
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