Synthesis and pharmacology of seleninic acid analogues of the inhibitory neurotransmitter gamma-aminobutyric acid.
作者信息
Stuhr-Hansen N, Ebert B, Krogsgaard-Larsen P, Kehler J
机构信息
Department of Chemistry, University of Copenhagen, Denmark.
出版信息
Org Lett. 2000 Jan;2(1):7-9. doi: 10.1021/ol991093w.
PMID:10814232
Abstract
[structure: see text] The first seleninic acid analogues of gamma-aminobutyric acid (GABA) and of the specific GABA(A) agonist piperidine-4-carboxylic acid (isonipecotic acid), 1 and 2, respectively, have been synthesized and shown to be potent agonists at the GABA receptors.
摘要
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