血液透析对慢性肾盂肾炎患者外周淋巴细胞肉碱水平的影响。

Effect of haemodialysis on peripheral lymphocyte carnitine levels in patients with chronic pyelonephritis.

作者信息

Alhomida A S

机构信息

Department of Biochemistry, King Saud University, College of Science, Riyadh, Saudi Arabia.

出版信息

Br J Biomed Sci. 1999;56(3):194-8.

PMID:10824328

Abstract

The effect of haemodialysis on peripheral blood lymphocyte levels of total carnitine (TC), free carnitine (FC) and acylcarnitine (AC), and on the ratio of AC to FC, is investigated in 20 healthy subjects (13 men and seven women) and 27 patients (10 men and 17 women) with chronic pyelonephritis. The mean predialysis peripheral lymphocyte levels of TC, FC and AC were not significantly different from those in the healthy controls (P > 0.05). However, after haemodialysis, peripheral lymphocyte levels of TC, FC and AC decreased significantly, compared with either predialysis (TC: 40%, FC: 37%, AC: 52%) or healthy controls (TC: 61%, FC: 63%, AC: 50%) (P < 0.01). Furthermore, after haemodialysis the AC/FC ratio was significantly higher, compared with either predialysis (41%) or healthy controls (38%) (P < 0.01).

摘要

在20名健康受试者（13名男性和7名女性）以及27名慢性肾盂肾炎患者（10名男性和17名女性）中，研究了血液透析对外周血淋巴细胞中总肉碱（TC）、游离肉碱（FC）和酰基肉碱（AC）水平以及AC与FC比值的影响。透析前外周淋巴细胞中TC、FC和AC的平均水平与健康对照组相比无显著差异（P>0.05）。然而，血液透析后，与透析前（TC：40%，FC：37%，AC：52%）或健康对照组（TC：61%，FC：63%，AC：50%）相比，外周淋巴细胞中TC、FC和AC水平显著降低（P<0.01）。此外，血液透析后AC/FC比值显著高于透析前（41%）或健康对照组（38%）（P<0.01）。