慢性大麻吸食者细胞介导免疫反应性的改变。

Alterations in the cellular-mediated immune responsiveness of chronic marihuana smokers.

作者信息

Petersen B H, Lemberger L, Graham J, Dalton B

出版信息

Psychopharmacol Commun. 1975;1(1):67-74.

Abstract

Chronic marihuana smokers and matched nonsmokers were compared with respect to several aspects of both their humoral and cellular immune system. Immunoglobulin and complement levels, SMA 12 and hematologic values from marihuana smokers did not differ significantly from those obtained from nonsmokers. However, the number of T-lymphocytes with respect to the ratio of T and B-lymphocytes in the peripheral blood was lowered in marihuana smokers. In addition, phytohemagglutinin stimulation of lymphocytes was apparently less effective in smokers. The polymorphonuclear leukocytes (PNM) from the blood of smokers contained fewer cells capable of phagocytizing yeast cells than did PMN from nonsmokers. While marihuana smoking does appear to affect immune mechanisms at no time in these studies were any deleterious physiological effects that could be directly associated with the alterations in the immune system observed in the marihuana smokers.

摘要

对慢性大麻烟民和相匹配的非烟民的体液免疫系统和细胞免疫系统的多个方面进行了比较。大麻烟民的免疫球蛋白、补体水平、SMA 12和血液学值与非烟民相比无显著差异。然而，大麻烟民外周血中T淋巴细胞数量相对于T和B淋巴细胞的比例有所降低。此外，烟民的淋巴细胞对植物血凝素的刺激反应明显较弱。与非烟民的多形核白细胞（PMN）相比，烟民血液中的多形核白细胞能够吞噬酵母细胞的数量更少。虽然吸食大麻似乎确实会影响免疫机制，但在这些研究中，从未观察到任何与大麻烟民免疫系统改变直接相关的有害生理影响。