通过Eph受体和ephrin信号传导对细胞行为的调控。

Control of cell behaviour by signalling through Eph receptors and ephrins.

作者信息

Mellitzer G, Xu Q, Wilkinson D G

机构信息

Division of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, NW7 1AA, UK.

出版信息

Curr Opin Neurobiol. 2000 Jun;10(3):400-8. doi: 10.1016/s0959-4388(00)00095-7.

DOI:10.1016/s0959-4388(00)00095-7

PMID:10851175

Abstract

Eph receptor tyrosine kinases and ephrins mediate contact-dependent cell interactions that regulate the repulsion and adhesion mechanisms involved in the guidance and assembly of cells. Recent work has revealed a role of overlapping Eph receptor and ephrin expression in modulating neuronal growth cone repulsion, and has shown that bidirectional activation restricts intermingling and communication between cell populations. In addition, progress has been made in understanding how Eph receptors and ephrins control cell adhesion.

摘要

Eph受体酪氨酸激酶和ephrin介导接触依赖性细胞相互作用，这些相互作用调节细胞导向和组装过程中涉及的排斥和黏附机制。最近的研究揭示了重叠的Eph受体和ephrin表达在调节神经元生长锥排斥中的作用，并表明双向激活限制了细胞群体之间的混合和通讯。此外，在理解Eph受体和ephrin如何控制细胞黏附方面也取得了进展。