Khandwala H M, McCutcheon I E, Flyvbjerg A, Friend K E
Section of Endocrine Neoplasia & Hormonal Disorders, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Endocr Rev. 2000 Jun;21(3):215-44. doi: 10.1210/edrv.21.3.0399.
Several decades of basic and clinical research have demonstrated that there is an association between the insulin-like growth factors (IGFs) and neoplasia. We begin with a brief discussion of the function and regulation of expression of the IGFs, their receptors and the IGF-binding proteins (IGFBPs). A number of investigational interventional strategies targeting the GH or IGFs are then reviewed. Finally, we have assembled the available scientific knowledge about this relationship for each of the major tumor types. The tumors have been grouped together by organ system and for each of the major tumors, various key elements of the relationship between IGFs and tumor growth are discussed. Specifically these include the presence or absence of autocrine IGF-I and IGF-II production; presence or absence of IGF-I and IGF-II receptor expression; the expression and functions of the IGFBPs; in vitro and in vivo experiments involving therapeutic interventions; and available results from clinical trials evaluating the effect of GH/IGF axis down-regulation in various malignancies.
数十年的基础和临床研究表明，胰岛素样生长因子（IGFs）与肿瘤形成之间存在关联。我们首先简要讨论IGFs、其受体以及IGF结合蛋白（IGFBPs）的功能和表达调控。然后回顾了一些针对生长激素或IGFs的研究性干预策略。最后，我们汇总了关于每种主要肿瘤类型这种关系的现有科学知识。肿瘤按器官系统进行了分组，对于每种主要肿瘤，讨论了IGFs与肿瘤生长关系的各种关键要素。具体包括自分泌IGF-I和IGF-II产生的有无；IGF-I和IGF-II受体表达的有无；IGFBPs的表达和功能；涉及治疗干预的体外和体内实验；以及评估生长激素/IGF轴下调在各种恶性肿瘤中作用的临床试验的现有结果。
