Kreyden O P, Böni R, Burg G
Dermatologische Klinik, Universitätsspital Zürich.
Praxis (Bern 1994). 2000 May 18;89(21):909-15.
Hyperhidrosis is defined as an excess of sweating over the amount necessary for thermoregulation. Essential focal hyperhidrosis is a overactivity of the sweat glands of the axilla, palms and soles probably due to a disorder of the sympathetic nervous system. The therapy is difficult, even though there are many therapeutic options. Beside the effort to treat the psychovegetative disorder (autogenic training or acupuncture), there are efforts to seal the lumen of terminal sweat ducts using aluminiumchlorhydroxide application or iontophoresis. Surgery has the aim to eliminate sweat glands either by excision or by denervation. It is also possible to use chemical denervation with systemic anticholinergics. Only recently the local chemodenervation with injections of botulinum toxin (BTX) was added to the therapeutic tools of focal hyperhidrosis. We present an overview of several therapeutic options in consideration of BTX.
多汗症的定义是出汗超过体温调节所需的量。原发性局限性多汗症是腋窝、手掌和脚底的汗腺过度活跃，可能是由于交感神经系统紊乱所致。尽管有许多治疗选择，但治疗仍很困难。除了努力治疗精神植物神经紊乱（自生训练或针灸）外，还有人尝试通过应用氢氯化铝或离子电渗疗法封闭终末汗腺管腔。手术的目的是通过切除或去神经支配来消除汗腺。也可以使用全身性抗胆碱能药物进行化学去神经支配。直到最近，局部注射肉毒杆菌毒素（BTX）进行化学去神经支配才被添加到局限性多汗症的治疗手段中。我们考虑到BTX，对几种治疗选择进行了概述。
