Nance M A, Nuttall F Q, Econs M J, Lyles K W, Viles K D, Vance J M, Pericak-Vance M A, Speer M C
Park Nicollet Clinic and Department of Neurology, Hennepin County Medical Center, Minneapolis, MN, USA.
Am J Med Genet. 2000 Jun 19;92(5):303-7. doi: 10.1002/1096-8628(20000619)92:5<303::aid-ajmg2>3.0.co;2-e.
Paget disease of the bone is a common skeletal disorder. Recently, a gene for Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization of a large pedigree of Paget disease and demonstrate that the Paget disease gene in this pedigree is not linked to the region on 18q, thus confirming linkage heterogeneity.
Zotero 插件