成人侵袭性非霍奇金淋巴瘤的管理

The management of adult aggressive non-Hodgkin's lymphomas.

作者信息

Couderc B, Dujols J P, Mokhtari F, Norkowski J L, Slawinski J C, Schlaifer D

机构信息

Groupe de Radiothérapie et d'Oncologie médicale des Pyrénées (GROP), chemin de l'Ormeau, 65000, Tarbes, France.

出版信息

Crit Rev Oncol Hematol. 2000 Jul;35(1):33-48. doi: 10.1016/s1040-8428(99)00037-2.

DOI:10.1016/s1040-8428(99)00037-2

PMID:10863150

Abstract

Aggressive non-Hodgkin's lymphona include diffuse large B-cell lymphoma, anaplastic large cell lymphona, and different peripheral T-cell lymphomas. An international prognostic index has been developed including age, serum LDH, performance status, and extranodal involvement. For localized aggressive lymphoma, the preferred treatment is 3-4 CHOP and radiation therapy, with a cure rate of 70-80%. For disseminated aggressive lymphoma, current regimens have a cure rate of less than 40%. Innovative strategies, including dose escalation, autologus stem cell support, new drugs, and immunotherapy are being explored to improve these results.

摘要

侵袭性非霍奇金淋巴瘤包括弥漫性大B细胞淋巴瘤、间变性大细胞淋巴瘤和不同类型的外周T细胞淋巴瘤。已经制定了一个国际预后指数，包括年龄、血清乳酸脱氢酶、体能状态和结外受累情况。对于局限性侵袭性淋巴瘤，首选治疗方案是3 - 4个周期的CHOP方案联合放射治疗，治愈率为70 - 80%。对于播散性侵袭性淋巴瘤，目前的治疗方案治愈率低于40%。正在探索创新策略，包括剂量递增、自体干细胞支持、新药和免疫疗法，以改善这些结果。