Marquardt G, Niebauer T, Schick U, Lorenz R
Neurosurgical Clinic, Johann Wolfgang von Goethe-University, Frankfurt am Main, Germany.
J Neurol Neurosurg Psychiatry. 2000 Jul;69(1):127-30. doi: 10.1136/jnnp.69.1.127.
To evaluate the long term sequelae of perimesencephalic subarachnoid haemorrhage (PMSAH).
Twenty one consecutive patients were studied. All patients were examined by CT, angiography, MRI, multimodal evoked potentials, and transcranial Doppler sonography. All relevant clinical data during hospital stay and outcome at discharge were obtained by reviewing the charts. Long term follow up was evaluated by reviewing the outpatient files and dedicated outpatient review. Patients were specifically questioned about their perceived recovery, residual complaints, and present occupational status.
Apart from the initial CT confirming the diagnosis of PMSAH all other examinations disclosed no abnormalities. None of the patients developed any complications during hospital stay, and all patients were discharged in good clinical condition and without neurological deficits. At long term follow up 62% of the patients had residual complaints consisting of headaches, irritability, depression, forgetfulness, weariness, and diminished endurance. Apart from four patients who had already retired before the PMSAH, only seven of the remaining 17 patients (41%) returned to their previous occupation, whereas nine patients (53%) retired from work and one man became unemployed. One patient had a recurrence of PMSAH 31 months after the first event.
PMSAH can have considerable long term psychosocial sequelae, and may also recur. Prognosis may not be as good as previously reported.
评估大脑中脑周围蛛网膜下腔出血(PMSAH)的长期后遗症。
对连续21例患者进行研究。所有患者均接受了CT、血管造影、MRI、多模式诱发电位和经颅多普勒超声检查。通过查阅病历获取住院期间所有相关临床资料及出院时的结局。通过查阅门诊病历和专门的门诊复查评估长期随访情况。专门询问患者关于他们感知到的恢复情况、残留症状及目前的职业状况。
除最初的CT确诊PMSAH外,所有其他检查均未发现异常。住院期间无患者出现任何并发症,所有患者出院时临床状况良好且无神经功能缺损。在长期随访中,62%的患者有残留症状,包括头痛、易怒、抑郁、健忘、疲倦和耐力下降。除4例在PMSAH发生前已退休的患者外,其余17例患者中只有7例(41%)恢复了之前的工作,而9例患者(53%)退休,1例男性失业。1例患者在首次发病31个月后PMSAH复发。
PMSAH可产生相当严重的长期心理社会后遗症,且可能复发。预后可能不如先前报道的那么好。