[急性眼压升高的模型与实验性治疗（作者译）]

[Model and the experimental therapy of acute increase of intraocular pressure (author's transl)].

作者信息

Bunin A J, Jakovlev A A, Komlev N A

出版信息

Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1976 Nov 18;201(1):101-10. doi: 10.1007/BF00410152.

Abstract

Comparative experiments were carried out on 63 rabbits to study the acute increase in intraocular pressure which develops in the eye after introduction of prostaglandin F2 (instillations, subconjunctival injections) and other substances (hypertonic solution of sodium chloride, and reopirin). Tonometry, tonography, and radioisotope studies of aqueous humor (24Na, albumin-labeled 131I) were done. Differences in the display and mechanisms of acute increase of intraocular pressure were marked following administration of prostaglandin and a hypertonic solution of sodium chloride. It is stated that prostaglandin increases the permeability of the blood-aqueous humor barrier for the 24Na ions in comparison with hypertonic solution of sodium chloride, and that the eye, under the influence of prostaglandin, heightens intraocular pressure. Pretreatment with dizinon (etamsilat) reduces the increase in intraocular pressure caused by prostaglandin.

摘要

对63只兔子进行了对比实验，以研究在眼内滴注前列腺素F2、结膜下注射前列腺素F2以及注入其他物质（氯化钠高渗溶液和雷奥匹林）后眼内压的急性升高情况。进行了眼压测量、眼压描记以及房水的放射性同位素研究（24Na、白蛋白标记的131I）。在给予前列腺素和氯化钠高渗溶液后，眼内压急性升高的表现和机制存在明显差异。结果表明，与氯化钠高渗溶液相比，前列腺素可增加血-房水屏障对24Na离子的通透性，并且在前列腺素的影响下，眼睛眼压升高。用二嗪农（乙胺磺酸盐）预处理可降低前列腺素引起的眼内压升高。