Gough S C
Division of Medical Sciences, University of Birmingham, United Kingdom.
Endocrinol Metab Clin North Am. 2000 Jun;29(2):255-66. doi: 10.1016/s0889-8529(05)70130-4.
Graves' disease is a complex autoimmune disorder in which several genetic susceptibility loci and environmental factors are likely to contribute to the development of disease. HLA and the CTLA-4 gene region have been established as susceptibility loci, although the magnitude of their contributions seems to vary between data sets and geographic populations. Genome-wide searches are beginning to identify new loci, including GD-1, GD-2, and GD-3, although these loci have only been found in one data set. Additional loci are likely to be identified via a combination of genome-wide linkage analysis and allelic association analysis of candidate genes.
格雷夫斯病是一种复杂的自身免疫性疾病，其中几个遗传易感位点和环境因素可能促成了该病的发生。HLA和细胞毒性T淋巴细胞相关抗原4（CTLA-4）基因区域已被确定为易感位点，尽管它们在不同数据集和不同地理人群中的作用程度似乎有所不同。全基因组搜索已开始识别新的位点，包括GD-1、GD-2和GD-3，尽管这些位点仅在一个数据集中被发现。通过全基因组连锁分析和候选基因的等位基因关联分析相结合，可能会识别出更多的位点。
