Carpi A, Nicolini A, Sagripanti A, Righi C, Menchini Fabris F, Di Coscio G
Department of Reproduction and Aging, University of Pisa, Italy.
Am J Clin Pathol. 2000 Jun;113(6):872-7. doi: 10.1309/JCU6-Y4DC-LEVM-HBFJ.
The palpable thyroid nodules with a fine-needle aspiration (FNA) diagnosis of microfollicular nodule or suspected cancer usually are excised; however, most of them are proved benign by postoperative histologic examination. We reviewed the clinical and pathologic data for patients with thyroid nodules with an FNA diagnosis of microfollicular nodule or suspected cancer; nodules also were examined by large-needle aspiration biopsy (LNAB) to assess whether the distinction achieved by LNAB into pure microfollicular or mixed microfollicular-macrofollicular nodules could be used preoperatively to better predict malignancy. One hundred fourteen nodules of this type were excised. The prevalence of cancer was 22% (14/63) among the microfollicular and 4% (2/51) among the microfollicular-macrofollicular nodules at LNAB. These data indicate that histologic examination of the LNAB specimen can be used for preoperative selection of thyroid nodules diagnosed by FNA as a microfollicular nodule or suspected cancer.
可触及的甲状腺结节，若细针穿刺抽吸活检（FNA）诊断为微滤泡结节或疑似癌症，通常会进行切除；然而，术后组织学检查显示其中大多数为良性。我们回顾了FNA诊断为微滤泡结节或疑似癌症的甲状腺结节患者的临床和病理数据；结节还接受了粗针穿刺活检（LNAB），以评估通过LNAB区分出的纯微滤泡或微滤泡-大滤泡混合性结节是否可在术前用于更好地预测恶性肿瘤。共切除了114个此类结节。在LNAB中，微滤泡结节的癌症患病率为22%（14/63），微滤泡-大滤泡混合性结节的癌症患病率为4%（2/51）。这些数据表明，LNAB标本的组织学检查可用于术前选择FNA诊断为微滤泡结节或疑似癌症的甲状腺结节。
