海弗利克假说：一种体内测试方法。
Hayflick's hypothesis: an approach to in vivo testing.
作者信息
Reincke U, Burlington H, Cronkite E P, Laissue J
出版信息
Fed Proc. 1975 Jan;34(1):71-5.
PMID:1088946
Abstract
The experimental evidence relating to the hypothesis of finite cellular life is reviewed. It is emphasized that even if somatic cell production were limited its total potential would have to be vast to provide for extensive cellular regeneration. The actual limit of reproductive cell life would therefore not likely be reached in a normal life-span. It is proposed to test the hypothesis by deliberate exhaustion of stem-cell reserve, and iron-55 cytocide is described as an experimental system that might be applicable.
摘要
本文综述了与有限细胞寿命假说相关的实验证据。需要强调的是，即使体细胞的产生是有限的，其总潜能也必须非常巨大，才能实现广泛的细胞再生。因此，在正常寿命范围内，生殖细胞寿命的实际极限不太可能达到。建议通过有意耗尽干细胞储备来检验这一假说，并介绍了铁-55细胞毒素作为一种可能适用的实验系统。
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