二氧化碳气腹期间不同充气压力对小鼠模型肺转移发展的影响。
The influence of different insufflation pressures during carbon dioxide pneumoperitoneum on the development of pulmonary metastasis in a mouse model.
作者信息
Ishida H, Murata N, Yokoyama M, Ishizuka N, Takeuchi I, Odaka A, Shimomura K, Fujioka M, Idezuki Y
机构信息
Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan.
出版信息
Surg Endosc. 2000 Jun;14(6):578-81. doi: 10.1007/s004640000098.
BACKGROUND
The effects of different insufflation pressures on the development of pulmonary metastasis was investigated in a mouse laparoscopy model.
METHODS
BALB/C mice intravenously inoculated with colon 26 cells were randomized to one of five treatment groups (10 mice per group): pneumoperitoneum at different pressures of 5, 10 or 15 mmHg; full laparotomy for 60 min; or anesthesia control. Cancer nodules on the lung surface 19 days postoperatively were compared between groups.
RESULTS
(a) As compared with the control group, pneumoperitoneum at 10 and 15 mmHg and laparotomy enhanced the growth of pulmonary metastases (p < 0.01). (b) The growth of metastases also was greater in laparotomy group mice than in mice undergoing pneumoperitoneum at 5 and 10 mmHg (p < 0.05).
CONCLUSIONS
These results suggest that the effects of different insufflation pressures on the growth of pulmonary metastases are not identical, and that pneumoperitoneum with high pressure may promote pulmonary metastases similar to those with laparotomy.
背景
在小鼠腹腔镜模型中研究了不同气腹压力对肺转移发生发展的影响。
方法
将经静脉接种结肠26细胞的BALB/C小鼠随机分为五个治疗组之一（每组10只小鼠）：分别施加5、10或15 mmHg不同压力的气腹；全腹切开60分钟；或麻醉对照。比较术后19天各组肺表面的癌结节情况。
结果
（a）与对照组相比，10和15 mmHg气腹及剖腹术可促进肺转移瘤生长（p < 0.01）。（b）剖腹术组小鼠转移瘤的生长也大于接受5和10 mmHg气腹的小鼠（p < 0.05）。
结论
这些结果表明，不同气腹压力对肺转移瘤生长的影响并不相同，高压气腹可能与剖腹术一样促进肺转移。
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