口服甲氨蝶呤治疗幼年慢性关节炎患儿的红细胞甲氨蝶呤与疾病活动度
Erythrocyte-methotrexate and disease activity in children treated with oral methotrexate for juvenile chronic arthritis.
作者信息
Kristensen K, Nielsen S, Karup Pedersen F, Zak M
机构信息
Paediatric Clinic 2, the Juliane Marie Centre, the National University Hospital Rigshospitalet, Copenhagen, Denmark.
出版信息
Scand J Rheumatol. 2000;29(3):187-9. doi: 10.1080/030097400750002085.
The concentration of methotrexate (MTX) in erythrocytes (E-MTX) was measured twice with three months interval in 21 children suffering from juvenile chronic arthritis (JCA). At the same time joint score, visual analogue scale (VAS), and laboratory parameters (CRP, WBC, PMNs, and ALAT) were obtained. There was only a weak insignificant correlation between the dose of MTX/m2 and E-MTX (r=0.24, p=0.11). No significant relations between the clinical or laboratory parameters and E-MTX was found. However, ALAT above normal range was associated with a lower dose of MTX (p=0.02) and lower VAS (p=0.02), indicating that toxicity may be associated with less articular discomfort. At present we consider routine determination of E-MTX in children with JCA of limited value.
对21例青少年慢性关节炎（JCA）患儿的红细胞中甲氨蝶呤（MTX）浓度（E-MTX）进行了两次测量，间隔三个月。同时获取关节评分、视觉模拟量表（VAS）以及实验室参数（C反应蛋白、白细胞、中性粒细胞和谷丙转氨酶）。MTX剂量/m²与E-MTX之间仅存在微弱的无显著相关性（r=0.24，p=0.11）。未发现临床或实验室参数与E-MTX之间存在显著关系。然而，谷丙转氨酶高于正常范围与较低剂量的MTX（p=0.02）和较低的VAS（p=0.02）相关，表明毒性可能与较少的关节不适有关。目前我们认为常规测定JCA患儿的E-MTX价值有限。
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