大鼠的母性关怀、海马突触发生与认知发展

Maternal care, hippocampal synaptogenesis and cognitive development in rats.

作者信息

Liu D, Diorio J, Day J C, Francis D D, Meaney M J

机构信息

Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, Departments of Psychiatry and Neurology & Neurosurgery, McGill University, 6875 Boul. LaSalle, Montréal H4H 1R3, Canada.

出版信息

Nat Neurosci. 2000 Aug;3(8):799-806. doi: 10.1038/77702.

DOI:10.1038/77702

PMID:10903573

Abstract

We report that variations in maternal care in the rat promote hippocampal synaptogenesis and spatial learning and memory through systems known to mediate experience-dependent neural development. Thus, the offspring of mothers that show high levels of pup licking and grooming and arched-back nursing showed increased expression of NMDA receptor subunit and brain-derived neurotrophic factor (BDNF) mRNA, increased cholinergic innervation of the hippocampus and enhanced spatial learning and memory. A cross-fostering study provided evidence for a direct relationship between maternal behavior and hippocampal development, although not all neonates were equally sensitive to variations in maternal care.

摘要

我们报告称，大鼠母体护理的差异通过已知介导经验依赖性神经发育的系统促进海马体突触形成以及空间学习和记忆。因此，表现出高水平舔舐和梳理幼崽以及弓背哺乳行为的母鼠所产的后代，其NMDA受体亚基和脑源性神经营养因子（BDNF）mRNA的表达增加，海马体的胆碱能神经支配增强，空间学习和记忆能力也得到提高。一项交叉寄养研究为母体行为与海马体发育之间的直接关系提供了证据，尽管并非所有新生儿对母体护理差异的敏感度都相同。