连续七天输注左旋多巴对大鼠日常节律的影响。

Effects of a seven-day continuous infusion of L-DOPA on daily rhythms in the rat.

作者信息

Simon N, Mouchet J, Bruguerolle B

机构信息

Laboratoire de Pharmacologie Médicale (Développement et Pathologie du Mouvement, UMR-FRE), Faculté de Médecine de Marseille, Université de la Méditerranée, 27, Bd J. Moulin F-13385, Cedex 5, Marseille, France.

出版信息

Eur J Pharmacol. 2000 Jul 28;401(1):79-83. doi: 10.1016/s0014-2999(00)00422-2.

DOI:10.1016/s0014-2999(00)00422-2

PMID:10915840

Abstract

The present study was conducted to evaluate the effect of L-3, 4-dihydroxyphenylalanine (L-DOPA) on the daily rhythms of temperature, heart rate and locomotor activity in rats that received a 7-day continuous infusion. Our results indicate that L-DOPA does not induce a loss of the daily rhythmicity of temperature, heart rate and locomotor activity but modifies the main parameters of these rhythms, e.g. it increased the MESOR (midline estimating statistic of rhythm) of temperature and heart rate and increased the amplitude of temperature but decreased the amplitude of heart rate. Taking into account these results obtained after constant rate delivery, we now plan to investigate the effects of DOPA therapy by changing the time of its administration.

摘要

本研究旨在评估L-3,4-二羟基苯丙氨酸（L-DOPA）对接受7天连续输注的大鼠体温、心率和运动活动日节律的影响。我们的结果表明，L-DOPA不会导致体温、心率和运动活动日节律的丧失，但会改变这些节律的主要参数，例如，它增加了体温和心率的MESOR（节律中线估计统计量），增加了体温的振幅，但降低了心率的振幅。考虑到恒速给药后获得的这些结果，我们现在计划通过改变给药时间来研究多巴治疗的效果。