拟南芥LUP1将氧化角鲨烯转化为多种三萜醇和一种三萜二醇。

Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol.

作者信息

Segura M J, Meyer M M, Matsuda S P

机构信息

Department of Chemistry and Department of Biochemistry and Cell Biology, Rice University, 6100 South Main Street, Houston, Texas 77005, USA.

出版信息

Org Lett. 2000 Jul 27;2(15):2257-9. doi: 10.1021/ol006016b.

DOI:10.1021/ol006016b

PMID:10930257

Abstract

The Arabidopsis thaliana LUP1 gene encodes an enzyme that converts oxidosqualene to pentacyclic triterpenes. Lupeol and beta-amyrin were previously reported as LUP1 products. Further investigation described here uncovered the additional products germanicol, taraxasterol, psi-taraxasterol, and 3,20-dihydroxylupane. These results suggest that the 80 known C(30)H(50)O compounds that are structurally consistent with being oxidosqualene cyclase products may be derived from fewer than 80 enzymes and that some C(30)H(52)O(2) compounds may be direct cyclization products of oxidosqualene.

摘要

拟南芥LUP1基因编码一种将氧化角鲨烯转化为五环三萜的酶。羽扇豆醇和β-香树脂醇此前被报道为LUP1的产物。此处描述的进一步研究发现了另外的产物，即德国醇、蒲公英甾醇、假蒲公英甾醇和3,20 - 二羟基羽扇烷。这些结果表明，80种已知的结构上与氧化角鲨烯环化酶产物一致的C(30)H(50)O化合物可能源自少于80种的酶，并且一些C(30)H(52)O(2)化合物可能是氧化角鲨烯的直接环化产物。