Akagi T, Ogawa S, Ino T, Iwasa M, Echigo S, Kishida K, Baba K, Matsushima M, Hamaoka K, Tomita H, Ishii M, Kato H
Department of Pediatrics, Kurume University School of Medicine, Kurume, Japan.
J Pediatr. 2000 Aug;137(2):181-6. doi: 10.1067/mpd.2000.107164.
To assess the current status of catheter intervention in Kawasaki disease and to evaluate its efficacy and outcome.
A questionnaire was sent to 55 major institutions in Japan.
A total of 58 procedures in 57 patients were reported. The median age at the time of intervention was 12.1 years. The procedures included percutaneous transluminal coronary angioplasty (PTCA; n = 34), percutaneous transluminal coronary rotational ablation (PTCRA; n = 13), directional coronary atherectomy (DCA; n = 4), and stent implantation (n = 7). The immediate success rate was 74% for PTCA, 100% for PTCRA, 100% for DCA, and 86% for stents. The interval from the onset of disease to intervention in successful PTCA (n = 25) was significantly shorter than that in unsuccessful PTCA (n = 9). Restenosis after PTCA was observed in 24%. Development of new coronary aneurysms was reported in 3 patients for PTCA, 2 for PTCRA, 3 for DCA, and 1 for stents. Except for the DCA, all new aneurysms were associated with the use of high-pressure balloon inflation. Two deaths were reported as acute complications.
Catheter intervention is a promising therapeutic strategy in the management of coronary stenosis caused by Kawasaki disease. Care should be paid to avoid acute coronary arterial complications and the development of new coronary aneurysms.
评估川崎病导管介入治疗的现状,并评价其疗效和结果。
向日本55家主要机构发送了调查问卷。
共报告了57例患者的58例手术。介入时的中位年龄为12.1岁。手术包括经皮腔内冠状动脉成形术(PTCA;n = 34)、经皮腔内冠状动脉旋磨术(PTCRA;n = 13)、冠状动脉定向斑块旋切术(DCA;n = 4)和支架植入术(n = 7)。PTCA的即刻成功率为74%,PTCRA为100%,DCA为100%,支架为86%。成功PTCA组(n = 25)从疾病发作到介入的时间间隔明显短于未成功PTCA组(n = 9)。PTCA术后再狭窄发生率为24%。PTCA有3例、PTCRA有2例、DCA有3例、支架有1例报告出现新的冠状动脉瘤。除DCA外,所有新动脉瘤均与使用高压球囊扩张有关。报告有2例死亡为急性并发症。
导管介入治疗是川崎病所致冠状动脉狭窄治疗的一种有前景的治疗策略。应注意避免急性冠状动脉并发症和新的冠状动脉瘤的发生。