细胞周期蛋白D1在乳腺发育中的特定作用。
A specific role for cyclin D1 in mammary gland development.
作者信息
Sicinski P, Weinberg R A
机构信息
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA.
出版信息
J Mammary Gland Biol Neoplasia. 1997 Oct;2(4):335-42. doi: 10.1023/a:1026391128117.
Cyclin D1 is a critical component of the core cell cycle machinery. Mice lacking cyclin D1 develop mammary glands that fail to undergo normal lobuloalveolar proliferation during pregnancy. Thus, cyclin D1 seems to play a critical role in pregnancy-induced proliferation of mammary epithelium. Cyclin D1 also participates in neoplasia, as the majority of human mammary carcinomas contain elevated levels of this cyclin.
细胞周期蛋白D1是核心细胞周期机制的关键组成部分。缺乏细胞周期蛋白D1的小鼠所发育出的乳腺，在孕期无法经历正常的小叶腺泡增殖。因此，细胞周期蛋白D1似乎在孕期诱导的乳腺上皮细胞增殖中发挥关键作用。细胞周期蛋白D1也参与肿瘤形成，因为大多数人类乳腺癌中这种细胞周期蛋白的水平都有所升高。
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